A New Technology Could Help Solve a DNA Mystery
The human genome’s inner workings could be revealed through new Cornell-developed technology.
Researchers from Oxford Nanopore Technologies, Weill Cornell Medicine, and the New York Genome Center have created a new technique to evaluate the three-dimensional structure of the human[{” attribute=””DNA, or how the genome folds, on a massive scale. The genome is the entire set of genetic instructions, either DNA or RNA, that allow an organism to function.
Using this technique, the researchers showed that groups of simultaneously interacting regulatory elements in the genome, as opposed to pairs of these elements, may influence cell activity, including gene expression. Their research, which was recently published in the journal Nature Biotechnology, may help clarify the connection between cellular identity and genome structure.
“Knowing the three-dimensional genome