Resveratrol may act on SIRT1 secondary to acting on AMPK in various tissues which is thought to be due to AMPK increasing levels of NAD+ in a cell, which is the cofactor for SIRT1. The opposite also holds true as abolishing SIRT1 activity prevents resveratrol from acting on AMPK, and SIRT1 has the ability to deacetylate the AMPK kinase known as LKB1 which would increase AMPK activity while abolishing SIRT1 prevents resveratrol from acting on AMPK.
11. Brown VA, Patel KR, Viskaduraki M, et al. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Res. 2010;70(22):9003-9011.
The reviews for Resveratrol Select show that this product helps to not only assist with , but it has many other positive benefits that make it worthwhile for people of all ages and sizes. Even those who are not trying to lose weight can still benefit from resveratrol.